Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
bkrb2_human 329 7.50x50 TM7 P => HisfsTer5 frameshift 1.656e-05 2 120804 0 None None SodiumPocket MicroSwitch
bkrb2_human 9 N-term M => V missense 8.238e-06 1 121388 0 nan 0.043
bkrb2_human 14 N-term R => C missense 0.06891 8365 121384 408 0.03 0.835
bkrb2_human 14 N-term R => L missense 8.238e-06 1 121390 0 0.33 0.433
bkrb2_human 14 N-term R => H missense 2.471e-05 3 121390 0 0.08 0.715
bkrb2_human 15 N-term E => K missense 8.238e-06 1 121388 0 nan 0.486
bkrb2_human 15 N-term E => D missense 2.471e-05 3 121384 0 nan 0.388
bkrb2_human 16 N-term D => A missense 0.0009557 116 121382 1 nan 0.728
bkrb2_human 18 N-term V => M missense 8.239e-06 1 121374 0 0.13 0.791
bkrb2_human 19 N-term P => H missense 8.24e-06 1 121360 0 nan 0.95
bkrb2_human 21 N-term T => M missense 1.649e-05 2 121318 0 0.2 0.897
bkrb2_human 25 N-term S => I missense 1.65e-05 2 121186 0 nan 0.216
bkrb2_human 25 N-term S => R missense 9.232e-06 1 108322 0 nan 0.216
bkrb2_human 26 N-term A => T missense 3.688e-05 4 108454 0 nan 0.002
bkrb2_human 27 N-term D => N missense 2.761e-05 3 108660 0 nan 0.028
bkrb2_human 27 N-term D => G missense 9.194e-06 1 108772 0 nan 0.001
bkrb2_human 27 N-term D => E missense 9.191e-06 1 108808 0 1.0 0.001
bkrb2_human 33 N-term L => F missense 9.162e-06 1 109148 0 nan 0.095
bkrb2_human 34 N-term Q => R missense 9.159e-06 1 109188 0 0.1 0.118
bkrb2_human 37 N-term T => I missense 9.147e-06 1 109322 0 0.07 0.031
bkrb2_human 38 N-term L => P missense 9.146e-06 1 109340 0 0.02 0.01
bkrb2_human 40 N-term G => R missense 0.000128 14 109368 0 0.23 0.01
bkrb2_human 40 N-term G => E missense 9.143e-06 1 109374 0 0.47 0.004
bkrb2_human 42 N-term F => V missense 2.743e-05 3 109366 0 0.56 0.001
bkrb2_human 43 N-term A => S missense 9.143e-06 1 109378 0 1.0 0.001
bkrb2_human 45 N-term S => R missense 9.145e-06 1 109354 0 0.28 0.002
bkrb2_human 46 N-term K => N missense 1.828e-05 2 109408 0 0.44 0.002
bkrb2_human 47 N-term C => Y missense 9.143e-06 1 109378 0 0.0 0.999
bkrb2_human 48 N-term P => L missense 9.139e-06 1 109416 0 0.68 0.002
bkrb2_human 50 N-term V => L missense 7.31e-05 8 109438 0 0.36 0.001
bkrb2_human 61 1.36x36 TM1 P => L missense 9.097e-06 1 109928 0 0.01 0.33
bkrb2_human 62 1.37x37 TM1 P => L missense 9.09e-06 1 110012 0 0.11 0.275
bkrb2_human 65 1.40x40 TM1 W => S missense 9.078e-06 1 110162 0 0.2 0.999
bkrb2_human 69 1.44x44 TM1 V => L missense 9.058e-06 1 110398 0 0.22 0.011
bkrb2_human 77 1.52x52 TM1 F => L missense 9.033e-06 1 110704 0 0.07 0.923
bkrb2_human 77 1.52x52 TM1 F => S missense 0.0001084 12 110706 1 0.0 0.991
bkrb2_human 78 1.53x53 TM1 V => F missense 9.039e-06 1 110630 0 0.0 1.0
bkrb2_human 81 1.56x56 TM1 V => I missense 6.326e-05 7 110656 0 0.05 0.196
bkrb2_human 90 2.37x37 TM2 T => M missense 9.061e-06 1 110364 0 0.0 0.989
bkrb2_human 90 2.37x37 TM2 T => K missense 9.061e-06 1 110364 0 0.0 0.967
bkrb2_human 97 2.44x44 TM2 G => R missense 9.039e-06 1 110632 0 0.0 0.977
bkrb2_human 100 2.47x47 TM2 A => V missense 9.035e-06 1 110676 0 0.0 1.0
bkrb2_human 101 2.48x48 TM2 A => T missense 9.932e-05 11 110756 0 0.04 0.461
bkrb2_human 109 2.56x56 TM2 G => E missense 8.992e-06 1 111208 0 0.09 0.938
bkrb2_human 115 2.62x62 TM2 I => T missense 8.948e-06 1 111754 0 0.02 0.212
bkrb2_human 116 2.63x63 TM2 T => I missense 8.941e-06 1 111850 0 0.02 0.928
bkrb2_human 117 2.64x64 TM2 I => T missense 2.679e-05 3 111968 0 0.03 0.876
bkrb2_human 120 2.67x67 TM2 N => S missense 8.909e-06 1 112246 0 0.31 0.11
bkrb2_human 122 23.49x49 ECL1 D => N missense 3.559e-05 4 112400 0 0.48 0.036
bkrb2_human 123 23.50x50 ECL1 W => R missense 8.891e-06 1 112470 0 0.0 1.0
bkrb2_human 126 3.21x21 TM3 G => R missense 8.879e-06 1 112630 0 0.0 0.999
bkrb2_human 128 3.23x23 TM3 T => M missense 0.000355 40 112672 0 0.08 0.383
bkrb2_human 131 3.26x26 TM3 R => H missense 8.866e-06 1 112786 0 0.0 0.983
bkrb2_human 132 3.27x27 TM3 V => M missense 1.773e-05 2 112816 0 0.13 0.249
bkrb2_human 135 3.30x30 TM3 A => V missense 8.878e-06 1 112636 0 0.77 0.012
bkrb2_human 140 3.35x35 TM3 N => H missense 8.89e-06 1 112486 0 0.0 1.0
bkrb2_human 149 3.44x44 TM3 M => T missense 3.584e-05 4 111604 0 0.69 0.101
bkrb2_human 153 3.48x48 TM3 I => T missense 8.994e-06 1 111190 0 0.02 0.92
bkrb2_human 154 3.49x49 TM3 D => E missense 1.801e-05 2 111038 0 0.0 1.0 SodiumPocket MicroSwitch
bkrb2_human 158 3.53x53 TM3 A => V missense 9.02e-06 1 110864 0 0.04 1.0 GP (contact)
bkrb2_human 167 34.55x55 ICL2 R => W missense 9.032e-06 1 110712 0 0.01 0.303 GP (contact)
bkrb2_human 168 34.56x56 ICL2 M => I missense 9.034e-06 1 110698 0 0.06 0.582 GP (contact)
bkrb2_human 169 34.57x57 ICL2 R => H missense 9.033e-06 1 110710 0 0.0 1.0 GP (contact)
bkrb2_human 170 4.38x38 TM4 G => S missense 4.516e-05 5 110706 0 0.18 0.542
bkrb2_human 170 4.38x38 TM4 G => C missense 9.033e-06 1 110706 0 0.03 0.975
bkrb2_human 171 4.39x39 TM4 V => M missense 3.612e-05 4 110734 0 0.04 0.983
bkrb2_human 171 4.39x39 TM4 V => A missense 9.03e-06 1 110738 0 1.0 0.654
bkrb2_human 172 4.40x40 TM4 R => C missense 0.0003974 44 110716 0 0.19 0.091
bkrb2_human 172 4.40x40 TM4 R => H missense 8.128e-05 9 110724 0 0.55 0.04
bkrb2_human 182 4.50x50 TM4 W => C missense 8.996e-06 1 111162 0 0.0 1.0
bkrb2_human 185 4.53x53 TM4 T => M missense 8.984e-06 1 111304 0 0.0 0.912
bkrb2_human 194 4.62x63 TM4 V => M missense 8.936e-06 1 111904 0 0.25 0.065
bkrb2_human 203 ECL2 D => N missense 8.918e-06 1 112130 0 0.14 0.027
bkrb2_human 206 ECL2 H => Y missense 8.912e-06 1 112210 0 1.0 0.005
bkrb2_human 207 ECL2 N => K missense 4.453e-05 5 112278 0 0.02 0.941
bkrb2_human 208 ECL2 V => I missense 8.011e-05 9 112346 0 0.63 0.322
bkrb2_human 209 ECL2 T => N missense 0.0001156 13 112432 0 0.04 0.991
bkrb2_human 209 ECL2 T => I missense 1.779e-05 2 112432 0 0.02 0.976
bkrb2_human 210 ECL2 A => T missense 4.443e-05 5 112540 0 0.0 0.919
bkrb2_human 214 ECL2 S => N missense 1.771e-05 2 112956 0 0.49 0.001
bkrb2_human 215 ECL2 Y => C missense 8.84e-06 1 113124 0 0.0 0.999
bkrb2_human 218 5.32x33 TM5 L => V missense 8.804e-06 1 113584 0 0.31 0.018
bkrb2_human 221 5.35x36 TM5 E => D missense 2.625e-05 3 114278 0 0.11 0.16 LB (Van der Waals)
bkrb2_human 226 5.40x41 TM5 M => T missense 2.598e-05 3 115470 0 0.36 0.003
bkrb2_human 230 5.44x45 TM5 V => I missense 4.287e-05 5 116630 0 1.0 0.003
bkrb2_human 231 5.45x46 TM5 V => M missense 5.982e-05 7 117016 0 0.02 0.841
bkrb2_human 238 5.52x52 TM5 S => N missense 8.354e-06 1 119698 0 0.36 0.2
bkrb2_human 245 5.59x59 TM5 M => T missense 8.283e-06 1 120724 0 0.18 0.0
bkrb2_human 247 5.61x61 TM5 I => S missense 8.276e-06 1 120836 0 0.0 0.991 GP (contact)
bkrb2_human 252 5.66x66 TM5 R => W missense 8.269e-06 1 120940 0 0.0 0.984 GP (contact)
bkrb2_human 252 5.66x66 TM5 R => Q missense 2.48e-05 3 120982 0 0.23 0.236 GP (contact)
bkrb2_human 255 5.69x69 TM5 E => K missense 3.304e-05 4 121054 0 0.27 0.477 GP (contact)
bkrb2_human 262 6.27x27 TM6 I => F missense 8.258e-06 1 121100 0 0.04 0.736
bkrb2_human 264 6.29x29 TM6 T => I missense 3.304e-05 4 121080 0 0.0 0.973 GP (contact)
bkrb2_human 269 6.34x34 TM6 T => S missense 8.301e-06 1 120466 0 0.1 0.444 SodiumPocket MicroSwitch
bkrb2_human 269 6.34x34 TM6 T => M missense 8.306e-06 1 120396 0 0.01 0.679 SodiumPocket MicroSwitch
bkrb2_human 270 6.35x35 TM6 V => M missense 8.307e-06 1 120382 0 0.36 0.016
bkrb2_human 271 6.36x36 TM6 L => V missense 4.158e-05 5 120264 0 0.0 0.999 GP (contact)
bkrb2_human 288 6.53x53 TM6 I => V missense 0.0001591 19 119452 0 0.55 0.058
bkrb2_human 291 6.56x56 TM6 F => L missense 8.382e-06 1 119308 0 0.25 0.058
bkrb2_human 294 6.59x59 TM6 T => A missense 8.383e-06 1 119282 0 0.02 0.99
bkrb2_human 294 6.59x59 TM6 T => M missense 2.519e-05 3 119102 0 0.06 0.998
bkrb2_human 297 6.62x62 TM6 R => C missense 3.354e-05 4 119262 0 0.04 0.939 LB (polar (charge-assisted hydrogen bond), Van der Waals)
bkrb2_human 299 6.64x64 TM6 G => S missense 3.348e-05 4 119488 0 0.5 0.002
bkrb2_human 299 6.64x64 TM6 G => R missense 8.369e-06 1 119488 0 0.42 0.004
bkrb2_human 304 7.25x24 TM7 C => G missense 8.336e-06 1 119960 0 0.0 1.0
bkrb2_human 306 7.27x26 TM7 D => N missense 3.33e-05 4 120116 0 0.31 0.01
bkrb2_human 307 7.28x27 TM7 E => K missense 2.497e-05 3 120166 0 0.23 0.046 LB (polar (charge-assisted hydrogen bond), Van der Waals)
bkrb2_human 308 7.29x28 TM7 R => C missense 2.496e-05 3 120216 0 0.1 0.436
bkrb2_human 308 7.29x28 TM7 R => H missense 1.663e-05 2 120264 0 0.77 0.001
bkrb2_human 311 7.32x31 TM7 D => N missense 4.149e-05 5 120498 0 0.06 0.661 LB (polar (charge-assisted hydrogen bond), Van der Waals)
bkrb2_human 311 7.32x31 TM7 D => Y missense 8.299e-06 1 120498 0 0.01 0.997 LB (polar (charge-assisted hydrogen bond), Van der Waals)
bkrb2_human 316 7.37x36 TM7 I => T missense 4.141e-05 5 120732 0 0.0 0.826
bkrb2_human 317 7.38x37 TM7 A => T missense 8.282e-06 1 120742 0 0.22 0.3
bkrb2_human 320 7.41x40 TM7 M => T missense 8.278e-06 1 120802 0 0.02 0.08
bkrb2_human 320 7.41x40 TM7 M => K missense 8.278e-06 1 120802 0 0.01 0.167
bkrb2_human 326 7.47x47 TM7 C => G missense 2.483e-05 3 120812 0 0.07 0.065
bkrb2_human 329 7.50x50 TM7 P => R missense 8.281e-06 1 120762 0 0.0 1.0 SodiumPocket MicroSwitch
bkrb2_human 333 7.54x54 TM7 V => M missense 0.0001242 15 120782 0 0.0 0.939
bkrb2_human 335 7.56x56 TM7 V => M missense 0.0002235 27 120786 0 0.0 0.999 GP (contact)
bkrb2_human 337 8.48x48 H8 K => R missense 0.001672 202 120788 1 0.07 0.267 GP (contact)
bkrb2_human 338 8.49x49 H8 R => C missense 2.484e-05 3 120760 0 0.01 0.794 GP (contact)
bkrb2_human 338 8.49x49 H8 R => H missense 2.483e-05 3 120802 1 1.0 0.006 GP (contact)
bkrb2_human 340 8.51x51 H8 R => Q missense 4.139e-05 5 120804 0 0.3 0.041 GP (contact)
bkrb2_human 344 8.55x55 H8 W => R missense 8.278e-06 1 120800 0 0.97 0.0
bkrb2_human 349 C-term G => R missense 5.801e-05 7 120672 0 0.68 0.004
bkrb2_human 349 C-term G => A missense 0.0001078 13 120620 0 0.79 0.004
bkrb2_human 350 C-term V => M missense 8.29e-06 1 120622 0 0.14 0.005
bkrb2_human 350 C-term V => G missense 7.461e-05 9 120620 0 0.05 0.035
bkrb2_human 354 C-term G => E missense 0.00592 712 120266 19 1.0 0.008
bkrb2_human 360 C-term P => L missense 1.679e-05 2 119086 0 0.07 0.478
bkrb2_human 368 C-term G => V missense 8.65e-06 1 115602 0 0.01 0.901
bkrb2_human 371 C-term R => G missense 8.742e-06 1 114384 0 0.0 0.838
bkrb2_human 371 C-term R => W missense 1.748e-05 2 114384 0 0.0 0.989
bkrb2_human 371 C-term R => Q missense 6.991e-05 8 114434 0 0.02 0.758
bkrb2_human 372 C-term T => A missense 6.127e-05 7 114240 0 0.0 0.963
bkrb2_human 374 C-term I => N missense 8.825e-06 1 113314 0 0.0 0.815
bkrb2_human 376 C-term V => M missense 0.0007484 84 112232 0 0.19 0.033
bkrb2_human 378 C-term R => C missense 8.971e-06 1 111468 0 0.04 0.871
bkrb2_human 378 C-term R => H missense 1.797e-05 2 111280 0 0.25 0.018
bkrb2_human 383 C-term L => Q missense 1.818e-05 2 110038 0 nan 0.779
bkrb2_human 385 C-term D => H missense 0.0002746 30 109246 0 nan 0.365
bkrb2_human 386 C-term W => C missense 5.516e-05 6 108766 0 nan 0.635
bkrb2_human 390 C-term R => K missense 9.271e-06 1 107866 0 nan 0.002


Residue

Diagrams

ICL1 K S S C ICL1ECL1 F D W L F ECL1ICL2 T M S M G R M R ICL2ECL2 T M K E Y S D E G H N V T A C V I S Y P ECL2ICL3 F K E ICL3ECL3 I L S ECL3N-term M F S P W K I S M F L S V R E D S V P T T A S F S A D M L N V T L Q G P T L N G T F A Q S K C P Q V E W L G N-termC-term Y Q G V C Q K G G C R S E P I Q M E N S M G T L R T S I S V E R Q I H K L Q D W A G S R Q C-term W L N T I Q P P F L W V L F V L A T L E N I F V L S V F C L H T V A E I Y L G N L A A A D L I L A C G L P F W A I T I S N N G E T L C R V V N A I I S M N L Y S S I C F L M L V S I D R Y L A L V K G V R W A K L Y S L V I W G C T L L L S S P M L V F R S L I W E V F T N M L L N V V G F L L P L S V I T F C T M Q I M Q V L R N N E M Q K I Q T E R R A T V L V L V V L L L F I I C W L P F Q I S T F L D T L H R L G S C Q D E R I I D V I T Q I A S F M A Y S N S C L N P L V Y V I V G K R S W E F R K K V
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